Transient receptor potential cation channel subfamily V member 4

Basic Information

Uniprot ID:	Q9HBA0
Secondary ID:	B7ZKQ6
Symbol:	TRPV4
Other Name:	VRL2,TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Calcium channel,Calmodulin-binding,Ion channel

Target Classification

Category I	Category II	Category III
Extracellular	Ion channel protein	Transient receptor potential channel

Related Compound

Target ID	Name	Interaction
D0090	RN1734	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	28073835	Compound ID	D0090
CAS	946387-07-1	Name	RN1734
Model	vitro	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	fibroblasts-to-myofibroblasts
Process III
Mechanism	Targeting PAI-1

Reference Record 2

PubMed ID	27496898	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 3

PubMed ID	25013893	Compound ID
CAS		Name
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation
Process III
Mechanism