Toll-like receptor 4

Basic Information

Uniprot ID: O00206
Secondary ID: A8K1Y8
Symbol: TLR4
Other Name: hToll,
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Receptor

Target Classification

Category I Category II Category III
Extracellular Toll-like receptor

Related Compound

Target ID Name Interaction
D0124 Resatorvid inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28634394 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Biliary fibrosis
Process I
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 27722989 Compound ID
CAS Name
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I regulate cytokines and growth factors
Process II
Process III prevenet collagen deposition
Mechanism Targeting TLR4/MyD88/ NF-κB signaling

Reference Record 3

PubMed ID 27585667 Compound ID D0124
CAS 243984-11-4 Name Resatorvid
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 25552658 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Muscle fibrosis
Process I attenue inflammation,macrophage polarization
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 24842252 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 20595685 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism Targeting TGF-β signaling

Reference Record 7

PubMed ID 18694726 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism

Reference Record 8

PubMed ID 18007026 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 17952090 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism Targeting LR4-Bambi–TGF-β signaling

Reference Record 10

PubMed ID 29379592 Compound ID
CAS Name
Model human Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 28966674 Compound ID D0124
CAS 243984-11-4 Name Resatorvid
Model mice Fibrosis Disease Peribronchial fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting TSLP