| Uniprot ID: | P78536 |
| Secondary ID: | O60226 |
| Symbol: | ADAM17 |
| Other Name: | CSVP,ADAM 17,Snake venom-like protease,TNF-alpha convertase,TNF-alpha-converting enzyme, |
| Class: | Single Protein |
| Type: | pro-fibrotic |
| Molecular Function: | Hydrolase,Metalloprotease,Protease |
| Category I | Category II | Category III |
|---|---|---|
| Extracellular | TIMP/MMP | MMP |
Reference Record 1
| PubMed ID | 27642633 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Renal fibrosis |
| Process I | regulate cytokines and growth factors | ||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting EGFR | ||
Reference Record 2
Reference Record 3
| PubMed ID | 19535569 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human | Fibrosis Disease | Renal fibrosis |
| Process I | attenue inflammation | ||
| Process II | cells proliferation | ||
| Process III | |||
| Mechanism | Targeting TGF-α | ||