| Uniprot ID: | P09486 |
| Secondary ID: | D3DQH9, Q6IBK4 |
| Symbol: | SPARC |
| Other Name: | ON,Basement-membrane protein 40,BM-40,Osteonectin,ON,Secreted protein acidic and rich in cysteine |
| Class: | Single Protein |
| Type: | pro-fibrotic |
| Molecular Function: | Calcium,Copper,Metal-binding |
| Category I | Category II | Category III |
|---|---|---|
| Extracellular | Secreted protein |
Reference Record 1
| PubMed ID | 21978691 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Systemic sclerosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 2
| PubMed ID | 21311029 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | HSCs migration | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting TGF-β1 and PDGF-BB | ||
Reference Record 3
| PubMed ID | 21264231 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human | Fibrosis Disease | Scar |
| Process I | |||
| Process II | fibroblasts proliferation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting TGF-β | ||
Reference Record 4
| PubMed ID | 20061390 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | fibroblasts apoptosis | ||
| Process III | |||
| Mechanism | Targeting β-catenin | ||
Reference Record 5
| PubMed ID | 18615449 | Compound ID | |
| CAS | Name | ||
| Model | vitro,rat | Fibrosis Disease | Liver fibrosis |
| Process I | attenue inflammation | ||
| Process II | myofibroblasts accumulation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||