| Uniprot ID: | Q15063 |
| Secondary ID: | B1ALD8 |
| Symbol: | POSTN |
| Other Name: | OSF2,PN,Osteoblast-specific factor 2,OSF-2 |
| Class: | Single Protein |
| Type: | pro/anti-fibrotic |
| Molecular Function: | Heparin-binding |
| Category I | Category II | Category III |
|---|---|---|
| Extracellular | Adhesion protein |
Reference Record 1
| PubMed ID | 28522687 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Renal fibrosis |
| Process I | |||
| Process II | cells proliferation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting ILK-Akt-mTOR pathway | ||
Reference Record 2
| PubMed ID | 27039906 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | HSCs activation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting αv integrin interaction axis | ||
Reference Record 3
| PubMed ID | 26249143 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | HSCs proliferation | ||
| Process III | |||
| Mechanism | Targeting TGF-β1/Smad signaling | ||
Reference Record 4
| PubMed ID | 25421393 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human | Fibrosis Disease | Scar |
| Process I | |||
| Process II | fibroblasts proliferation,fibroblasts differentiation | ||
| Process III | |||
| Mechanism | |||
Reference Record 5
| PubMed ID | 25369801 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human | Fibrosis Disease | Keloid |
| Process I | |||
| Process II | cells migration | ||
| Process III | |||
| Mechanism | Targeting ERK1/2 and FAK signaling | ||
Reference Record 6
| PubMed ID | 25304470 | Compound ID | |
| CAS | Name | ||
| Model | rat | Fibrosis Disease | Renal fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 7
| PubMed ID | 24788198 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Keloid |
| Process I | |||
| Process II | fibroblasts proliferation,fibroblasts migration,cells apoptosis | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Reference Record 8
| PubMed ID | 23043074 | Compound ID | |
| CAS | Name | ||
| Model | human,mice | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | cells proliferation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Reference Record 9
| PubMed ID | 22911870 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human,mice | Fibrosis Disease | Skin fibrosis |
| Process I | |||
| Process II | myofibroblasts differentiation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting PI3K/Akt | ||
Reference Record 10
| PubMed ID | 17632525 | Compound ID | |
| CAS | Name | ||
| Model | vitro,rat | Fibrosis Disease | Cardiac fibrosis |
| Process I | |||
| Process II | cells proliferation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Reference Record 11
| PubMed ID | 17408641 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Pancreatic fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||