Osteopontin

Basic Information

Uniprot ID: P10451
Secondary ID: B2RDA1
Symbol: SPP1
Other Name: BNSP,Bone sialoprotein 1,Nephropontin,Secreted phosphoprotein 1,SPP-1,Urinary stone protein,Uropontin
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Cytokine

Target Classification

Category I Category II Category III
Extracellular Other

Related Compound

Target ID Name Interaction
D0907 OPN-R3 aptamer

Fibrosis Related Property

Reference Record 1

PubMed ID 28595626 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts activation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1 signaling

Reference Record 2

PubMed ID 24902765 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 24871103 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 22858059 Compound ID
CAS Name
Model mice Fibrosis Disease Fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 22661273 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III
Mechanism Targeting TGF-β1

Reference Record 6

PubMed ID 22402440 Compound ID
CAS Name
Model human,mice Fibrosis Disease Systemic sclerosis
Process I attenue inflammation
Process II myofibroblasts differentiation,fibroblasts migration,myofibroblasts accumulation
Process III
Mechanism

Reference Record 7

PubMed ID 21962803 Compound ID D0907
CAS Name OPN-R3
Model vitro Fibrosis Disease Dermal fibrosis
Process I
Process II fibroblasts proliferation,cells migration
Process III
Mechanism

Reference Record 8

PubMed ID 21953216 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Scar
Process I attenue inflammation
Process II HSCs proliferation,HSCs migration
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 21953216 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSCs proliferation,HSCs migration
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 21734100 Compound ID
CAS Name
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II EMT,fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 21525025 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 20967826 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID 20720406 Compound ID
CAS Name
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID 20200330 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 19720619 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 19451692 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Muscle fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID 19246678 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 18

PubMed ID 16128620 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts proliferation,fibroblasts migration
Process III prevenet collagen deposition
Mechanism