| Uniprot ID: | Q15465 |
| Secondary ID: | A4D247, Q75MC9 |
| Symbol: | SHH |
| Other Name: | SHH,HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC,ShhN,Shh N-terminal processed signaling domains,ShhNp,Sonic hedgehog protein N-product,ShhN,Shh N-terminal processed signaling domainsspan class="attribution ECO303"span class="attributionHeader "1 Publicationspan class="showHideEvidence caret_grey displayThisInline"spanspanspan class="evidenceContainer" style="display:none"p class="attributionExplain"span class="context-help tooltipped-click html tipId-2"Manual assertion based on opinion insupisupspanpullidiv class="Q15465#ref16 referenceAttribution"div class="reference_header"Ref.16,ShhNpspan class="attribution ECO303"span class="attributionHeader "1 Publicationspan class="showHideEvidence caret_grey displayThisInline"spanspanspan class="evidenceContainer" style="display:none"p class="attributionExplain"span class="context-help tooltipped-click html tipId-2"Manual assertion based on opinion insupisupspanpullidiv class="Q15465#ref16 referenceAttribution"div class="reference_header"Ref.16 |
| Class: | Single Protein |
| Type: | pro/anti-fibrotic |
| Molecular Function: | Developmental protein,Hydrolase,Protease |
| Category I | Category II | Category III |
|---|---|---|
| Extracellular | Other |
Reference Record 1
| PubMed ID | 24744439 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human,mice | Fibrosis Disease | Renal fibrosis |
| Process I | |||
| Process II | fibroblasts proliferation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Reference Record 2
| PubMed ID | 22354771 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human | Fibrosis Disease | Systemic sclerosis |
| Process I | |||
| Process II | myofibroblasts differentiation,myofibroblasts accumulation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting COL1A1 and COL1A2 | ||
Reference Record 3
| PubMed ID | 22213086 | Compound ID | |
| CAS | Name | ||
| Model | human | Fibrosis Disease | Liver fibrosis |
| Process I | attenue inflammation | ||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting Hh pathway | ||
Reference Record 4
| PubMed ID | 18662193 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Muscle fibrosis |
| Process I | attenue inflammation | ||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||