Ribosomal protein S6 kinase beta-1

Basic Information

Uniprot ID: P23443
Secondary ID: B2R779
Symbol: RPS6KB1
Other Name: STK14A,S6K-beta-1,S6K1,70 kDa ribosomal protein S6 kinase 1,P70S6K1,p70-S6K 1,Ribosomal protein S6 kinase I,Serinethreonine-protein kinase 14A,p70 ribosomal S6 kinase alpha,p70 S6 kinase alpha,p70 S6K-alpha,p70 S6KA
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0177 LY-2584702 inhibitor
D0178 WP1066 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 27438654 Compound ID
CAS Name
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 26566903 Compound ID D0177
CAS 1082949-67-4 Name LY-2584702
Model vitro,mice Fibrosis Disease Subpleural fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting the S6K pathway

Reference Record 3

PubMed ID 26563331 Compound ID D0178
CAS 857064-38-1 Name WP1066
Model mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 20115955 Compound ID
CAS Name
Model human Fibrosis Disease Nephrogenic systemic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID 15677443 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation
Process III
Mechanism Targeting PI3K-Akt-p70S6K signaling