Dual specificity mitogen-activated protein kinase kinase 4

Basic Information

Uniprot ID: P45985
Secondary ID: B2R7N7
Symbol: MAP2K4
Other Name: JNKK1,MAP kinase kinase 4,MAPKK 4,JNK-activating kinase 1,MAPKERK kinase 4,MEK 4,SAPKERK kinase 1,SEK1,Stress-activated protein kinase kinase 1,SAPK kinase 1,SAPKK-1,SAPKK1,c-Jun N-terminal kinase kinase 1,JNKK
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase,Tyrosine-protein kinase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Fibrosis Related Property

Reference Record 1

PubMed ID 24721794 Compound ID
CAS Name
Model human,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1 signaling