Homeodomain-interacting protein kinase 2

Basic Information

Uniprot ID: Q9H2X6
Secondary ID: Q75MR7, Q8WWI4, Q9H2Y1
Symbol: HIPK2
Other Name:
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0539 BT173 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28220029 Compound ID D0539
CAS Name BT173
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1/Smad3 pathway

Reference Record 2

PubMed ID 27890429 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II HSC proliferation
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1/Smad3 signaling

Reference Record 3

PubMed ID 22689412 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 22406746 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II EMT,cells apoptosis
Process III prevenet collagen deposition
Mechanism