| Uniprot ID: | P60484 |
| Secondary ID: | B2R904 |
| Symbol: | PTEN |
| Other Name: | MMAC1,Mutated in multiple advanced cancers 1,Phosphatase and tensin homolog |
| Class: | Single Protein |
| Type: | anti-fibrotic |
| Molecular Function: | Hydrolase,Protein phosphatase |
| Category I | Category II | Category III |
|---|---|---|
| Intracellular | Enzyme | Phosphatase |
Reference Record 1
| PubMed ID | 28095306 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | macrophages polarization | ||
| Process III | |||
| Mechanism | Targeting PI3K/Akt/STAT6 signaling | ||
Reference Record 2
| PubMed ID | 24387036 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | fibroblasts proliferation,fibroblasts differentiation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting PI3-K-Akt-GSK3beta pathway | ||
Reference Record 3
| PubMed ID | 23239155 | Compound ID | |
| CAS | Name | ||
| Model | human,mice | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | fibroblasts proliferation,myofibroblasts differentiation,fibroblasts migration,fibroblasts apoptosis | ||
| Process III | |||
| Mechanism | Targeting PI3K/Pten/Akt pathway | ||
Reference Record 4
| PubMed ID | 21989717 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human | Fibrosis Disease | Scar |
| Process I | |||
| Process II | fibroblasts proliferation,fibroblasts apoptosis | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting PTEN/AKT pathway | ||
Reference Record 5
| PubMed ID | 29049990 | Compound ID | |
| CAS | Name | ||
| Model | mice | Fibrosis Disease | Renal fibrosis |
| Process I | attenue inflammation | ||
| Process II | fibroblasts proliferation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting PTEN/PI3K/Akt signaling pathway | ||