cGMP-specific 3',5'-cyclic phosphodiesterase

Basic Information

Uniprot ID:	O76074
Secondary ID:	A0AV69
Symbol:	PDE5A
Other Name:	PDE5,cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Allosteric enzyme,Hydrolase

Target Classification

Category I	Category II	Category III
Intracellular	Enzyme	Phosphodiesterase

Related Compound

Target ID	Name	Interaction
D0083	Vardenafil	inhibitor
D0239	Sildenafil	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	28196856	Compound ID	D0083
CAS	224785-90-4	Name	Vardenafil
Model	vitro,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II	macrophages polarization
Process III
Mechanism	Targeting PDE5- and CFTR-dependent mechanisms

Reference Record 2

PubMed ID	26410556	Compound ID	D0083
CAS	224785-90-4	Name	Vardenafil
Model	vitro	Fibrosis Disease	Dermal fibrosis
Process I
Process II	fibroblasts differetiation
Process III
Mechanism

Reference Record 3

PubMed ID	25416030	Compound ID	D0239
CAS	139755-83-2	Name	Sildenafil
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting CBP1

Reference Record 4

PubMed ID	17586695	Compound ID	D0239
CAS	139755-83-2	Name	Sildenafil
Model	vitro,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism