1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Basic Information


Uniprot ID: Q9P212
Secondary ID: A6NGW0
Symbol: PLCE1
Other Name: KIAA1516,Pancreas-enriched phospholipase C,Phosphoinositide phospholipase C-epsilon-1,Phospholipase C-epsilon-1,PLC-epsilon-1
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Guanine-nucleotide releasing factor,Hydrolase,Transducer


Target Classification


Category I Category II Category III
Intracellular Enzyme Phosphodiesterase

Related Compound



Fibrosis Related Property


Reference Record 1

PubMed ID 28093232 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Scar
Process I regulate cytokines and growth factors
Process II keratinocyte proliferation,keratinocyte migration
Process III prevenet collagen deposition
Mechanism Targeting Col6a1, Col17a1 and Ccl20