E3 ubiquitin-protein ligase RNF4

Basic Information


Uniprot ID: P78317
Secondary ID: B2R6D6, D6RF58, Q49AR8
Symbol: RNF4
Other Name: SNURF,RING finger protein 4,RING-type E3 ubiquitin transferase RNF4,Small nuclear ring finger protein,Protein SNURF
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Activator,DNA-binding,Transferase


Target Classification


Category I Category II Category III
Intracellular Enzyme Ligase

Related Compound



Fibrosis Related Property


Reference Record 1

PubMed ID 28143738 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation,regulate cytokines and growth factors
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β signaling