Ubl carboxyl-terminal hydrolase 18

Basic Information


Uniprot ID: Q9UMW8
Secondary ID: Q53Y90, Q6IAD9, Q9NY71
Symbol: USP18
Other Name: ISG43,43 kDa ISG15-specific protease,hUBP43,ISG15-specific-processing protease,Ubl thioesterase 18
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Hydrolase,Protease,Thiol protease


Target Classification


Category I Category II Category III
Intracellular Enzyme Hydrolase

Related Compound



Fibrosis Related Property


Reference Record 1

PubMed ID 27572150 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β-activated kinase 1-p38/c-Jun N-terminal kinase 1/2 signaling axis