Egl nine homolog 1

Basic Information

Uniprot ID:	Q9GZT9
Secondary ID:	Q8N3M8, Q9BZS8, Q9BZT0
Symbol:	EGLN1
Other Name:	C1orf12,Hypoxia-inducible factor prolyl hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Dioxygenase,Oxidoreductase

Target Classification

Category I	Category II	Category III
Intracellular	Enzyme	Oxidoreductase

Related Compound

Target ID	Name	Interaction
D0362	Cobalt chloride	inhibitor
D0363	Dimethyloxalylglycine	inhibitor
D0364	Mimosine	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	21825224	Compound ID	D0362
CAS	7646-79-9	Name	Cobalt chloride
Model	mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting AT(1)R

Reference Record 2

PubMed ID	21825224	Compound ID	D0363
CAS	89464-63-1	Name	Dimethyloxalylglycine
Model	mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting AT(1)R

Reference Record 3

PubMed ID	21777345	Compound ID	D0364
CAS	500-44-7	Name	Mimosine
Model	rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism