Aldose reductase

Basic Information

Uniprot ID:	P15121
Secondary ID:	B2R8N3
Symbol:	AKR1B1
Other Name:	ALDR1,AR,Aldehyde reductase,Aldo-keto reductase family 1 member B1
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Oxidoreductase

Target Classification

Category I	Category II	Category III
Intracellular	Enzyme	Oxidoreductase

Related Compound

Target ID	Name	Interaction
D0359	(Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl)	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	21913985	Compound ID	D0359
CAS	178881-14-6	Name	(Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl)
Model	rat	Fibrosis Disease	Liver fibrosis
Process I	attenue inflammation
Process II	HSCs activation
Process III	prevenet collagen deposition
Mechanism