Prostaglandin G/H synthase 2

Basic Information

Uniprot ID: P35354
Secondary ID: A8K802, Q16876
Symbol: PTGS2
Other Name: COX2,Cyclooxygenase-2,COX-2,PHS II,Prostaglandin H2 synthase 2,PGH synthase 2,PGHS-2,Prostaglandin-endoperoxide synthase 2
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Dioxygenase,Oxidoreductase,Peroxidase

Target Classification

Category I Category II Category III
Intracellular Enzyme Oxidoreductase

Related Compound

Target ID Name Interaction
D0181 Celecoxib inhibitor
D0507 Nimesulide inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 26458764 Compound ID D0181
CAS 169590-42-5 Name Celecoxib
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 25371970 Compound ID D0181
CAS 169590-42-5 Name Celecoxib
Model vitro,rabbit Fibrosis Disease Scar
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID 23922700 Compound ID D0181
CAS 169590-42-5 Name Celecoxib
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism Targeting VEGF/VEGFR-2

Reference Record 4

PubMed ID 21372163 Compound ID
CAS Name
Model mice Fibrosis Disease Pancreatic fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 20179298 Compound ID
CAS Name
Model mice Fibrosis Disease Intestinal fibrosis
Process I
Process II myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 17845691 Compound ID
CAS Name
Model human Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 7

PubMed ID 25656942 Compound ID D0181
CAS 169590-42-5 Name Celecoxib
Model rat Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 24462674 Compound ID D0181
CAS 169590-42-5 Name Celecoxib
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1/IL-2/COX-2/ETB receptor pathway

Reference Record 9

PubMed ID 11872629 Compound ID D0507
CAS 51803-78-2 Name Nimesulide
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism