Peroxisome proliferator-activated receptor alpha

Basic Information

Uniprot ID: Q07869
Secondary ID: B0G0X3
Symbol: PPARA
Other Name: NR1C1,PPAR-alpha,Nuclear receptor subfamily 1 group C member 1
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Activator,DNA-binding,Receptor

Target Classification

Category I Category II Category III
Intracellular Nuclear receptor NR1 family

Related Compound

Target ID Name Interaction
D0009 Arjunolic acid agonist
D0587 Osthol agonist

Fibrosis Related Property

Reference Record 1

PubMed ID 28821620 Compound ID D0009
CAS 465-00-9 Name Arjunolic acid
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting non-canonical TGF-β signaling

Reference Record 2

PubMed ID 25703085 Compound ID
CAS Name
Model human Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID 21854795 Compound ID D0587
CAS 484-12-8 Name Osthol
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κB