Nuclear receptor subfamily 1 group I member 2

Basic Information

Uniprot ID: O75469
Secondary ID: Q006P5
Symbol: NR1I2
Other Name: PXR,Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Activator,DNA-binding,Receptor

Target Classification

Category I Category II Category III
Intracellular Nuclear receptor NR1 family

Related Compound

Target ID Name Interaction
D0186 Pregnenolone Carbonitrile activator
D0420 Rifampicin agonist
D0421 Progesterone agonist
D0422 11β hydroxyprogesterone agonist
D0423 4A3COOHmethyl agonist

Fibrosis Related Property

Reference Record 1

PubMed ID 26302150 Compound ID D0186
CAS 1434-54-4 Name Pregnenolone Carbonitrile
Model rat Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 19432992 Compound ID D0186
CAS 1434-54-4 Name Pregnenolone Carbonitrile
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 3

PubMed ID 19432992 Compound ID D0420
CAS 13292-46-1 Name Rifampicin
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 4

PubMed ID 19432992 Compound ID D0421
CAS 57-83-0 Name Progesterone
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 5

PubMed ID 19432992 Compound ID D0422
CAS 600-57-7 Name 11β hydroxyprogesterone
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 6

PubMed ID 19432992 Compound ID D0423
CAS Name 4A3COOHmethyl
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 7

PubMed ID 16831602 Compound ID D0420
CAS 13292-46-1 Name Rifampicin
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,HSCs differentiation
Process III
Mechanism

Reference Record 8

PubMed ID 15595924 Compound ID D0186
CAS 1434-54-4 Name Pregnenolone Carbonitrile
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,HSCs differentiation
Process III prevenet collagen deposition
Mechanism