Nuclear receptor subfamily 4 group A member 1

Basic Information

Uniprot ID:	P22736
Secondary ID:	B4DML7
Symbol:	NR4A1
Other Name:	GFRP1,Early response protein NAK1,Nuclear hormone receptor NUR77,Nur77,Orphan nuclear receptor HMR,Orphan nuclear receptor TR3,ST-59,Testicular receptor 3
Class:	Single Protein
Type:	anti-fibrotic
Molecular Function:	DNA-binding,Receptor

Target Classification

Category I	Category II	Category III
Intracellular	Nuclear receptor	NR4 family

Related Compound

Target ID	Name	Interaction
D0229	Cytosporone B	agonist

Fibrosis Related Property

Reference Record 1

PubMed ID	25581517	Compound ID	D0229
CAS	321661-62-5	Name	Cytosporone B
Model	vitro,human,mice	Fibrosis Disease	Skin fibrosis
Process I
Process II	myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting Smad signaling

Reference Record 2

PubMed ID	25581517	Compound ID	D0229
CAS	321661-62-5	Name	Cytosporone B
Model	vitro,human,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting Smad signaling

Reference Record 3

PubMed ID	25581517	Compound ID	D0229
CAS	321661-62-5	Name	Cytosporone B
Model	vitro,human,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting Smad signaling

Reference Record 4

PubMed ID	25581517	Compound ID	D0229
CAS	321661-62-5	Name	Cytosporone B
Model	vitro,human,mice	Fibrosis Disease	Liver fibrosis
Process I
Process II	myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting Smad signaling