Signal transducer and activator of transcription 3

Basic Information

Uniprot ID: P40763
Secondary ID: A8K7B8
Symbol: STAT3
Other Name: APRF,Acute-phase response factor
Class: Single Protein
Type: pro/anti-fibrotic
Molecular Function: Activator,DNA-binding

Target Classification

Category I Category II Category III
Intracellular Other transcription factor Transcription activator

Related Compound

Target ID Name Interaction
D0185 C-188-9 inhibitor
D0491 Stattic inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28848189 Compound ID
CAS Name
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 2

PubMed ID 27524611 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 27153926 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 26324850 Compound ID D0185
CAS 432001-19-9 Name C-188-9
Model vitro,human,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts differetiation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 23303450 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Scar
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 25740948 Compound ID D0491
CAS 19983-44-9 Name Stattic
Model vitro,mice Fibrosis Disease Intestinal fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 29085226 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism