Endothelial PAS domain-containing protein 1

Basic Information

Uniprot ID: Q99814
Secondary ID: Q86VA2, Q99630
Symbol: EPAS1
Other Name: BHLHE73,EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2
Class: Single Protein
Type: pro/anti-fibrotic
Molecular Function: Activator,Developmental protein,DNA-binding

Target Classification

Category I Category II Category III
Intracellular Other transcription factor Transcription activator

Related Compound

Fibrosis Related Property

Reference Record 1

PubMed ID 26637636 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 24789906 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 23946285 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 21538443 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 19139726 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID 28900259 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism