MKL/myocardin-like protein 1

Basic Information

Uniprot ID:	Q969V6
Secondary ID:	Q8TCL1
Symbol:	MRTFA
Other Name:	KIAA1438,MRTF-A,MKLmyocardin-like protein 1,Megakaryoblastic leukemia 1 protein,Megakaryocytic acute leukemia protein
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Actin-binding

Target Classification

Category I	Category II	Category III
Intracellular	Other transcription factor	Transcription activator

Related Compound

Target ID	Name	Interaction
D0541	CCG-203971	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	28364121	Compound ID	D0541
CAS	1443437-74-8	Name	CCG-203971
Model	vitro,human	Fibrosis Disease	Scar
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting MRTF/SRF pathway

Reference Record 2

PubMed ID	20558820	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	cells proliferation,myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting SRF