Histone acetyltransferase p300

Basic Information

Uniprot ID: Q09472
Secondary ID: B1AKC2
Symbol: EP300
Other Name: P300,p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein propionyltransferase p300
Class: Epigenetics
Type: pro-fibrotic
Molecular Function: Acyltransferase,Transferase

Target Classification

Category I Category II Category III
Intracellular Epigenetics Writer

Related Compound

Target ID Name Interaction
D0532 L002 inhibitor
D0562 C646 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 26045780 Compound ID D0562
CAS 328968-36-1 Name C646
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting TGF-β1/Smad3 signaling

Reference Record 2

PubMed ID 15818659 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Skin fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 28933600 Compound ID D0532
CAS 321695-57-2 Name L002
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation,fibroblasts differentiation,fibroblasts migration
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 28933600 Compound ID D0532
CAS 321695-57-2 Name L002
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II fibroblasts proliferation,fibroblasts differentiation,fibroblasts migration
Process III prevenet collagen deposition
Mechanism