| Uniprot ID: | Q8N6T7 |
| Secondary ID: | B2RCD0 |
| Symbol: | SIRT6 |
| Other Name: | SIR2L6,Regulatory protein SIR2 homolog 6,SIR2-like protein 6 |
| Class: | Epigenetics |
| Type: | anti-fibrotic |
| Molecular Function: | Hydrolase |
| Category I | Category II | Category III |
|---|---|---|
| Intracellular | Epigenetics | Eraser |
Reference Record 1
| PubMed ID | 28659816 | Compound ID | |
| CAS | Name | ||
| Model | mice | Fibrosis Disease | Cardiac fibrosis |
| Process I | attenue inflammation | ||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Reference Record 2
| PubMed ID | 28536120 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting Bach1, an Nrf2 repressor | ||
Reference Record 3
| PubMed ID | 26987016 | Compound ID | |
| CAS | Name | ||
| Model | vitro,human | Fibrosis Disease | Epidural fibrosis |
| Process I | |||
| Process II | fibroblasts proliferation | ||
| Process III | |||
| Mechanism | Targeting miR-21 | ||
Reference Record 4
| PubMed ID | 28977842 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | EMT | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting TGF-β1/Smad3 signaling | ||