Dr AFC

Category I	Category II	Category III
Intracellular	Epigenetics	microRNA

Target ID	Name	Interaction
D1128	MiR-21a-5p antagonism	antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID	28817807	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	fibroblasts proliferation, fibroblasts migration
Process III	prevenet collagen deposition
Mechanism	Targeting Smad7 signaling pathway

Reference Record 2

PubMed ID	28714020	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	cells proliferation
Process III
Mechanism	Targeting BCL2, PTEN and IFNG

Reference Record 3

PubMed ID	28406477	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Liver fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	28396121	Compound ID	D1128
CAS		Name	MiR-21a-5p antagonism
Model	mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting Notch2 signaling

Reference Record 5

PubMed ID	28335740	Compound ID
CAS		Name
Model	vitro,human,rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	fibroblasts proliferation
Process III
Mechanism	Targeting CADM1/STAT3 pathway

Reference Record 6

PubMed ID	27226339	Compound ID
CAS		Name
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	EMT
Process III	prevenet collagen deposition
Mechanism	Targeting ERK1 pathway

Reference Record 7

PubMed ID	27207585	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Scar
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID	26968995	Compound ID
CAS		Name
Model	vitro,rabbit	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting Smad7

Reference Record 9

PubMed ID	26865549	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	fibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID	26455824	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting DDAH1

Reference Record 11

PubMed ID	26376826	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I
Process II	EMT
Process III
Mechanism

Reference Record 12

PubMed ID	26338827	Compound ID
CAS		Name
Model	human,mice	Fibrosis Disease	Liver fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID	25896982	Compound ID
CAS		Name
Model	vitro,rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 14

PubMed ID	25896982	Compound ID
CAS		Name
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 15

PubMed ID	25892183	Compound ID
CAS		Name
Model	vitro,human,mice	Fibrosis Disease	Muscle fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting PTEN and SPRY-1

Reference Record 16

PubMed ID	25873777	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Muscle fibrosis
Process I
Process II	fibroblasts activation,fibroblasts proliferation,fibroblasts apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID	25769721	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 18

PubMed ID	25725128	Compound ID
CAS		Name
Model	human	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 19

PubMed ID	25418215	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting DUSP8,JNK and p38

Reference Record 20

PubMed ID	25357050	Compound ID
CAS		Name
Model	vitro,human	Fibrosis Disease	Keloid
Process I
Process II	fibroblasts proliferation,cells apoptosis
Process III
Mechanism	Targeting PTEN

Reference Record 21

PubMed ID	25303175	Compound ID
CAS		Name
Model	vitro,human	Fibrosis Disease	Liver fibrosis
Process I
Process II	EMT,HSCs activation,HSCs migration
Process III
Mechanism

Reference Record 22

PubMed ID	24887517	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	EMT
Process III
Mechanism	Targeting smad7

Reference Record 23

PubMed ID	24817011	Compound ID
CAS		Name
Model	vitro,human	Fibrosis Disease	Scar
Process I
Process II	fibroblasts activation,cells proliferation,cells apoptosis
Process III
Mechanism	Targeting hTERT

Reference Record 24

PubMed ID	24743145	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 25

PubMed ID	24335017	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III
Mechanism	Targeting FasL

Reference Record 26

PubMed ID	23657402	Compound ID
CAS		Name
Model	vitro,human,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II
Process III
Mechanism	Targeting TGF-β signaling

Reference Record 27

PubMed ID	23643356	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	cells activation
Process III
Mechanism	Targeting PTEN/Akt signaling

Reference Record 28

PubMed ID	23443810	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting MMP9/TIMP1

Reference Record 29

PubMed ID	23441172	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	EMT
Process III
Mechanism	Targeting PDCD4 and SPRY1

Reference Record 30

PubMed ID	23292313	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting Smad7

Reference Record 31

PubMed ID	22960625	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 32

PubMed ID	22923342	Compound ID
CAS		Name
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 33

PubMed ID	22760500	Compound ID
CAS		Name
Model	vitro,human,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting Sprouty1

Reference Record 34

PubMed ID	22344686	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	myofibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism

Reference Record 35

PubMed ID	22307526	Compound ID
CAS		Name
Model	vitro,human	Fibrosis Disease	Systemic sclerosis
Process I
Process II
Process III
Mechanism

Reference Record 36

PubMed ID	20978354	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 37

PubMed ID	20625373	Compound ID
CAS		Name
Model	vitro,human,mice	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III
Mechanism	Targeting TGF-β signaling

Reference Record 38

PubMed ID	19043405	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	cells apoptosis
Process III
Mechanism	Targeting MAP kinase signaling

Reference Record 39

PubMed ID	23469132	Compound ID
CAS		Name
Model	vitro,mice,human	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Uniprot ID:
Secondary ID:
Symbol:	miR-21
Other Name:
Class:	Epigenetics
Type:	pro/anti-fibrotic
Molecular Function:

microRNA-21

Basic Information

Target Classification

Related Compound

Fibrosis Related Property