Rap guanine nucleotide exchange factor 4

Basic Information


Uniprot ID: Q8WZA2
Secondary ID: B2R7R3
Symbol: RAPGEF4
Other Name: CGEF2,Exchange factor directly activated by cAMP 2,Exchange protein directly activated by cAMP 2,EPAC 2,cAMP-regulated guanine nucleotide exchange factor II,cAMP-GEFII
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Guanine-nucleotide releasing factor


Target Classification


Category I Category II Category III
Intracellular Other

Related Compound



Fibrosis Related Property


Reference Record 1

PubMed ID 26854595 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,HSCs activation
Process III prevenet collagen deposition
Mechanism Targeting Rap1