Protein-glutamine gamma-glutamyltransferase 2

Basic Information

Uniprot ID: P21980
Secondary ID: E1P5V9
Symbol: TGM2
Other Name: Tissue transglutaminase,Transglutaminase C,TG(C),TGC,TGase C,Transglutaminase H,TGase H,Transglutaminase-2,TGase-2
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Acyltransferase,Transferase

Target Classification

Category I Category II Category III
Both Enzyme

Related Compound

Target ID Name Interaction
D1126 AM2/169 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 25047228 Compound ID
CAS Name
Model cat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 24175906 Compound ID
CAS Name
Model vitro Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts migration
Process III
Mechanism

Reference Record 3

PubMed ID 21746810 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 21700912 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II cells migration
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 21067461 Compound ID D1126
CAS Name AM2/169
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID 18688035 Compound ID
CAS Name
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1

Reference Record 7

PubMed ID 15201665 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism