NACHT, LRR and PYD domains-containing protein 3

Basic Information

Uniprot ID:	Q96P20
Secondary ID:	A0A024R5Q0
Symbol:	NLRP3
Other Name:	C1orf7,Angiotensinvasopressin receptor AIIAVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Activator

Target Classification

Category I	Category II	Category III
Both	Transcription factor

Related Compound

Target ID	Name	Interaction
D0561	MCC950	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	28591554	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I	regulate cytokines and growth factors
Process II	inhibit EMT
Process III
Mechanism	Targeting TGF-β1 signaling

Reference Record 2

PubMed ID	26103560	Compound ID	D0561
CAS	210826-40-7	Name	MCC950
Model	mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 3

PubMed ID	25131433	Compound ID
CAS		Name
Model	human	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID	20688930	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism