| Uniprot ID: | P09429 |
| Secondary ID: | A5D8W9 |
| Symbol: | HMGB1 |
| Other Name: | HMG1,High mobility group protein 1,HMG-1 |
| Class: | Single Protein |
| Type: | pro-fibrotic |
| Molecular Function: | DNA-binding |
Reference Record 1
| PubMed ID | 26126535 | Compound ID | |
| CAS | Name | ||
| Model | vitro,rat | Fibrosis Disease | Pulmonary fibrosis |
| Process I | |||
| Process II | EMT | ||
| Process III | |||
| Mechanism | Targeting TGF-β1/Smad2/3 signaling | ||
Reference Record 2
| PubMed ID | 23696886 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | HSCs proliferation,HSCs migration | ||
| Process III | |||
| Mechanism | Targeting PI3K/Akt and JNK | ||
Reference Record 3
| PubMed ID | 22314397 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Cystic fibrosis |
| Process I | attenue inflammation | ||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 4
| PubMed ID | 21142449 | Compound ID | |
| CAS | Name | ||
| Model | human | Fibrosis Disease | Cardiac fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 5
| PubMed ID | 18658107 | Compound ID | |
| CAS | Name | ||
| Model | human,mice | Fibrosis Disease | Cystic fibrosis |
| Process I | attenue inflammation | ||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 6
| PubMed ID | 18441281 | Compound ID | |
| CAS | Name | ||
| Model | human,mice | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | cells accumulation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||