General Information
- Project ID
- OEP001200
- Project Name
- Marine water metagenomes of Yap trench
- Description
- Asgard is a recently discovered superphylum of archaea that appears to include the closest archaeal relatives of eukaryotes1-5. Debate continues as to whether the archaeal ancestor of eukaryotes belongs within the Asgard superphylum or whether this ancestor is a sister group to all other archaea (that is, a two-domain versus a three-domain tree of life)6-8. Here we present a comparative analysis of 162 complete or nearly complete genomes of Asgard archaea, including 75 metagenome-assembled genomes that-to our knowledge-have not previously been reported. Our results substantially expand the phylogenetic diversity of Asgard and lead us to propose six additional phyla that include a deep branch that we have provisionally named Wukongarchaeota. Our phylogenomic analysis does not resolve unequivocally the evolutionary relationship between eukaryotes and Asgard archaea, but instead-depending on the choice of species and conserved genes used to build the phylogeny-supports either the origin of eukaryotes from within Asgard (as a sister group to the expanded Heimdallarchaeota-Wukongarchaeota branch) or a deeper branch for the eukaryote ancestor within archaea. Our comprehensive protein domain analysis using the 162 Asgard genomes results in a major expansion of the set of eukaryotic signature proteins. The Asgard eukaryotic signature proteins show variable phyletic distributions and domain architectures, which is suggestive of dynamic evolution through horizontal gene transfer, gene loss, gene duplication and domain shuffling. The phylogenomics of the Asgard archaea points to the accumulation of the components of the mobile archaeal 'eukaryome' in the archaeal ancestor of eukaryotes (within or outside Asgard) through extensive horizontal gene transfer.
- Publications
-
Expanded diversity of Asgard archaea and their relationships with eukaryotes
Liu, Yang et al. “Expanded diversity of Asgard archaea and their relationships with eukaryotes.” Nature vol. 593,7860 (2021): 553-557.
(PMID: 33911286) (DOI: 10.1038/s41586-021-03494-3)
Project information
- Experiments
- 1
Experiment ID Experiment name Experiment type Create Date OEX013536 Yap Metagenomic 2021-05-14 - Samples
- 9
Sample ID Sample Name Sample Subject Type Organism Tissue Create Date OES092919 Yap4 Environment non-host marine metagenome N/A 2021-05-14 OES092920 Yap30 Environment non-host marine metagenome N/A 2021-05-14 OES092921 Yap75 Environment non-host marine metagenome N/A 2021-05-14 OES092922 Yap100 Environment non-host marine metagenome N/A 2021-05-14 OES092923 Yap125 Environment non-host marine metagenome N/A 2021-05-14 OES092924 Yap200 Environment non-host marine metagenome N/A 2021-05-14 OES092925 Yap150 Environment non-host marine metagenome N/A 2021-05-14 OES092926 Yap500 Environment non-host marine metagenome N/A 2021-05-14 OES092927 Yap2000 Environment non-host marine metagenome N/A 2021-05-14 - Runs
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9
Run ID Run Name Experiment Sample Data Num Create Date OER183682 OER_Meng_2105141439 OEX013536 OES092919 2 2021-05-14 OER183683 OER_Meng_2105141449 OEX013536 OES092922 2 2021-05-14 OER183684 OER_Meng_2105141450 OEX013536 OES092921 2 2021-05-14 OER183685 OER_Meng_2105141450 OEX013536 OES092923 2 2021-05-14 OER183686 OER_Meng_2105141451 OEX013536 OES092925 2 2021-05-14 OER183687 OER_Meng_2105141452 OEX013536 OES092924 2 2021-05-14 OER183688 OER_Meng_2105141453 OEX013536 OES092926 2 2021-05-14 OER183689 OER_Meng_2105141454 OEX013536 OES092927 2 2021-05-14 OER183691 OER_Meng_2105141503 OEX013536 OES092920 2 2021-05-14
Author Information
- Create Date
- 2020-10-12
- Last Modified
- 2021-06-10
- Submission
- Wen-Cong Huang
- Shenzhen University