General Information
- Project ID
- OEP004909
- Project Name
- Transcriptomic profiling of senescent human stromal cells upon medicinal intervention with rutin (human)
- Description
- Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using natural or synthetic agents would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of rutin, a bioactive phytochemical component derived from natural plants specifically ginkgo boliva, in targeting senescent cells via suppression of the SASP. This study demonstrates the efficacy of rutin as medicinal agent in controlling the influence of senescent human stromal cells and provides a strong rationale for its future use in aging intervention and geriatric medicine. Overall design: Examination of in vitro efficacy of rutin, a polyphenolic compound in treating human senescent stromal cells (PSC27 line). Ginkgo biloba products are widely consumed herbal supplements that contain ingredients with anti-oxidant potentials. However, the active agents in ginkgo biloba extracts (GBE) remain unclear, and its major ingredients such as rutin has not been extensively investigated in cellular senescence. This assay was performed beyond previous studies reporting the effects of GBE in anti-diabetic, anti-cataract therapy, anti-inflammation and anti-tumor therapies.
- Publications
-
Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy
Liu H, Xu Q, Wufuer H, et al. Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy. Aging Cell. 2024;23(1):e13921. doi:10.1111/acel.13921
(PMID: 37475161) (DOI: 10.1111/acel.13921) - Related Links
- https://onlinelibrary.wiley.com/doi/10.1111/acel.13921
Project information
- Experiments
- 1
Experiment ID Experiment name Experiment type Create Date OEX026988 transcriptomic prostate Transcriptomic 2023-12-27 - Samples
- 9
Sample ID Sample Name Sample Subject Type Organism Tissue Create Date OES345426 sample 620 Human Homo sapiens prostate 2023-12-27 OES345427 sample 621 Human Homo sapiens prostate 2023-12-27 OES345428 sample 622 Human Homo sapiens prostate 2023-12-27 OES345429 sample 623 Human Homo sapiens prostate 2023-12-27 OES345430 sample 624 Human Homo sapiens prostate 2023-12-27 OES345431 sample 625 Human Homo sapiens prostate 2023-12-27 OES345432 sample 626 Human Homo sapiens prostate 2023-12-27 OES345433 sample 627 Human Homo sapiens prostate 2023-12-27 OES345434 sample 628 Human Homo sapiens prostate 2023-12-27 - Runs
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9
Run ID Run Name Experiment Sample Data Num Create Date OER452454 SRR17143620 OEX026988 OES345426 2 2023-12-27 OER452455 SRR17143621 OEX026988 OES345427 2 2023-12-27 OER452456 SRR17143622 OEX026988 OES345428 2 2023-12-27 OER452457 SRR17143623 OEX026988 OES345429 2 2023-12-27 OER452458 SRR17143624 OEX026988 OES345430 2 2023-12-27 OER452459 SRR17143625 OEX026988 OES345431 2 2023-12-27 OER452460 SRR17143626 OEX026988 OES345432 2 2023-12-27 OER452461 SRR17143627 OEX026988 OES345433 2 2023-12-27 OER452462 SRR17143628 OEX026988 OES345434 2 2023-12-27
Author Information
- Create Date
- 2023-12-27
- Last Modified
- 2024-02-05
- Submission
- Yu Sun
- Shanghai Institute of Nutrition and Health, CAS