General Information
- Project ID
- OEP004913
- Project Name
- PDK4-dependent hypercatabolism and lactate production of senescence cells promotes cancer malignancy
- Description
- Technical advances in next generation sequencing (NGS) has revolutionized system-based analysis of genome-wide expression, cellular pathways and responses. We performed this study to establish the transcriptomic profiles of human prostate cancer cell lines exposed to conditioned media from human primary stromal cells engineered to express pyruvate dehydrogenase kinase 4 (PDK4), a key enzyme that is correlated with glucose metabolism, negatively regulates the conversion of pyruvate to acetyl-CoA and plays important roles in cancer progression and multiple other pathological events.
- Publications
-
PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy
Dou X, Fu Q, Long Q, et al. PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy. Nat Metab. 2023;5(11):1887-1910. doi:10.1038/s42255-023-00912-w
(PMID: 37903887) (DOI: 10.1038/s42255-023-00912-w) - Related Links
- https://www.nature.com/articles/s42255-023-00912-w
Project information
- Experiments
- 2
- Samples
- 30
Sample ID Sample Name Sample Subject Type Organism Tissue Create Date OES345463 sample 8242 Human Homo sapiens prostate 2023-12-28 OES345464 sample 8243 Human Homo sapiens prostate 2023-12-28 OES345465 sample 8244 Human Homo sapiens prostate 2023-12-28 OES345466 sample 8245 Human Homo sapiens prostate 2023-12-28 OES345467 sample 8246 Human Homo sapiens prostate 2023-12-28 OES345468 sample 8247 Human Homo sapiens prostate 2023-12-28 OES345469 sample 8248 Human Homo sapiens prostate 2023-12-28 OES345470 sample 8249 Human Homo sapiens prostate 2023-12-28 OES345471 sample 8250 Human Homo sapiens prostate 2023-12-28 OES345472 sample 8251 Human Homo sapiens prostate 2023-12-28 OES345473 sample 8252 Human Homo sapiens prostate 2023-12-28 OES345474 sample 8253 Human Homo sapiens prostate 2023-12-28 OES345475 sample 6450 Human Homo sapiens prostate 2023-12-28 OES345476 sample 6451 Human Homo sapiens prostate 2023-12-28 OES345477 sample 6452 Human Homo sapiens prostate 2023-12-28 OES345478 sample 6453 Human Homo sapiens prostate 2023-12-28 OES345479 sample 6454 Human Homo sapiens prostate 2023-12-28 OES345480 sample 6455 Human Homo sapiens prostate 2023-12-28 OES345481 sample 6456 Human Homo sapiens prostate 2023-12-28 OES345482 sample 6457 Human Homo sapiens prostate 2023-12-28 OES345483 sample 6458 Human Homo sapiens prostate 2023-12-28 OES345484 sample 3230 Animalia Mus musculus lung 2023-12-28 OES345485 sample 3231 Animalia Mus musculus lung 2023-12-28 OES345486 sample 3232 Animalia Mus musculus lung 2023-12-28 OES345487 sample 3233 Animalia Mus musculus lung 2023-12-28 OES345488 sample 3234 Animalia Mus musculus lung 2023-12-28 OES345489 sample 3235 Animalia Mus musculus lung 2023-12-28 OES345490 sample 3236 Animalia Mus musculus lung 2023-12-28 OES345491 sample 3237 Animalia Mus musculus lung 2023-12-28 OES345492 sample 3238 Animalia Mus musculus lung 2023-12-28 - Runs
-
30
Run ID Run Name Experiment Sample Data Num Create Date OER452488 SRR18268242 OEX026990 OES345463 2 2023-12-28 OER452489 SRR18268243 OEX026990 OES345464 2 2023-12-28 OER452490 SRR18268244 OEX026990 OES345465 2 2023-12-28 OER452491 SRR18268245 OEX026990 OES345466 2 2023-12-28 OER452492 SRR18268246 OEX026990 OES345467 2 2023-12-28 OER452493 SRR18268247 OEX026990 OES345468 2 2023-12-28 OER452494 SRR18268248 OEX026990 OES345469 2 2023-12-28 OER452495 SRR18268249 OEX026990 OES345470 2 2023-12-28 OER452496 SRR18268250 OEX026990 OES345471 2 2023-12-28 OER452497 SRR18268251 OEX026990 OES345472 2 2023-12-28 OER452498 SRR18268252 OEX026990 OES345473 2 2023-12-28 OER452499 SRR18268253 OEX026990 OES345474 2 2023-12-28 OER452500 SRR22996450 OEX026991 OES345475 2 2023-12-28 OER452501 SRR22996451 OEX026991 OES345476 2 2023-12-28 OER452502 SRR22996452 OEX026991 OES345477 2 2023-12-28 OER452503 SRR22996453 OEX026991 OES345478 2 2023-12-28 OER452504 SRR22996454 OEX026991 OES345479 2 2023-12-28 OER452505 SRR22996455 OEX026991 OES345480 2 2023-12-28 OER452506 SRR22996456 OEX026991 OES345481 2 2023-12-28 OER452507 SRR22996457 OEX026991 OES345482 2 2023-12-28 OER452508 SRR22996458 OEX026991 OES345483 2 2023-12-28 OER452509 SRR22263230 OEX026991 OES345484 2 2023-12-28 OER452510 SRR22263231 OEX026991 OES345485 2 2023-12-28 OER452511 SRR22263232 OEX026991 OES345486 2 2023-12-28 OER452512 SRR22263233 OEX026991 OES345487 2 2023-12-28 OER452513 SRR22263234 OEX026991 OES345488 2 2023-12-28 OER452514 SRR22263235 OEX026991 OES345489 2 2023-12-28 OER452515 SRR22263236 OEX026991 OES345490 2 2023-12-28 OER452516 SRR22263237 OEX026991 OES345491 2 2023-12-28 OER452517 SRR22263238 OEX026991 OES345492 2 2023-12-28
Author Information
- Create Date
- 2023-12-28
- Last Modified
- 2024-02-05
- Submission
- Yu Sun
- Shanghai Institute of Nutrition and Health, CAS