DescriptionRNA-seq of photorespiratory bypass plants
Used IDNODEP00000033  
OEP000073
DescriptionRNA-seq and MeRIP-seq data
OEP004978
DescriptionCarotid endarterectomy (CEA) has been widely employed to treat Carotid artery stenosis (CAS). Yet, the impact of CEA on CAS-induced cognitive impairment and underlying mechanisms remain poorly understood.
OEP005154
DescriptionCancer associated fibroblasts (CAFs) have been shown to play a crucial role in regulating tumor chemotherapy and immunotherapy resistance. The therapeutic value of CAFs in prostate cancer has largely not been studied. Our research revealed that CAFs secrete CCL5, which promotes the upregulation of androgen receptor (AR) expression in prostate cancer cells, leading to resistance to enzalutamide therapy. Furthermore, CCL5 also enhances the expression of tumor programmed death-ligand 1 (PD-L1), resulting in immune escape. Mechanistically, CCL5 binds to its receptor, CC motif chemokine receptor 5 (CCR5), on prostate cancer cells and activates the AKT signaling pathway, leading to the upregulation of AR and PD-L1. The CCR5 antagonist maraviroc to inhibit the CAFs mediated CCL5 signaling pathway can effectively reduce the expression of AR and PD-L1, and improve the efficacy of enzalutamide. Together, CAFs can enhance the expression of AR and PD-L1 by paracrine CCL5 binding to CCR5 activated AKT pathway in prostate cancer, resulting in enzalutamide resistance and immune escape. And targeting CCL5-CCR5 communication as a promising treatment method to improve the effectiveness of enzalutamide.
OEP005133
Description
OEP005148
DescriptionWe transplanted gut microbiota from human donors with ASD or typically developing (TD) controls into antibiotic-treated mice. We performed 16S rRNA gene sequencing on the gut microbiota of both parental and offspring mice.
OEP005037
DescriptionWe transplanted gut microbiota from human donors with ASD or typically developing (TD) controls into antibiotic-treated mice.Then, we analyzed gene expression in the brains of the mice.
OEP005038
DescriptionMetabolomics of serum from pregnant mice (Mus musculus)
OEP005141
DescriptionExpression Data for Multidimensional Study of the Heterogeneity of Leukemia Cells in t(8;21) AML Identifies the Subtype with Poor Outcome
OEP005137
Description
OEP004923