DescriptionThe WGS of PDC with hydroxyurea of treatment
OEP005197
Description
OEP005199
DescriptionThe cohort includes 5 samples
OEP005203
DescriptionThis cohort includes 20 patients.
OEP005189
Description
OEP005206
Description
OEP001391
DescriptionThe spleen plays a critical role in the pathogenesis of leukemia. However, our understanding of the splenic niche in regulating leukemic cells is very limited. Herein, we report identification of such a unique splenic niche population. Induced expression of a secreted protein Gremlin1 in a genetically engineered mouse model restrains the disease progression of chronic myeloid leukemia (CML) and synergizes with first-line tyrosine kinase inhibitor (TKI) treatment, whereas blockade of the Gremlin1 protein by a monoclonal antibody enhances the CML development. Intriguingly, the CML-promoting effect of anti-Gremlin1 antibody is most evident in the spleen but not in the bone marrow, which can be abrogated by splenectomy. Genetic ablation of Gremlin1+ cells leads to an accelerated CML progression. Together with analysis of single cell RNA-seq data, we find that Gremlin1 marks a unique stromal cell population in the spleen of not only mice, but also humans. Mechanistically, Gremlin1 induces apoptosis of leukemia stem cells (LSCs) via antagonizing the BMP pathway. Together, we demonstrate that Gremlin1 and Gremlin1+ cells are key defensive niche components in the spleen to limit the progression of CML, revealing an unprecedented mechanism for the body to fight off leukemia.
OEP003642
DescriptionAcute lymphoblastic leukemia (ALL) poses formidable challenges in adult patients, considering its heterogeneous nature and relatively unfavorable prognosis among hematological malignancies.The metabolic interplay between body organs and bone marrow (BM) in ALL remains poorly understood, with limited knowledge beyond BM microenvironment in promoting ALL or how the body responds.
OEP005155
Description武汉开发部分-测试提交
OEP004707
Description
OEP005194