Details

spike_validated_epi_4

  • Epitope_Source: Sars-Cov-2 epitope in PDB database
  • Antibody:Antibody C105 FAB
  • Literature:
    Barnes CO, West AP Jr, Huey-Tubman KE, Hoffmann MAG, Sharaf NG, Hoffman PR, Koranda N, Gristick HB, Gaebler C, Muecksch F, Lorenzi JCC, Finkin S, Hägglöf T, Hurley A, Millard KG, Weisblum Y, Schmidt F, Hatziioannou T, Bieniasz PD, Caskey M, Robbiani DF, Nussenzweig MC, Bjorkman PJ. Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies. Cell. 2020 Aug 20;182(4):828-842.e16. doi: 10.1016/j.cell.2020.06.025. Epub 2020 Jun 24. PMID: 32645326; PMCID: PMC7311918.
  • PDBID:6XCM, 6XCN
  • PDB_Method:EM
  • PDB_Resolution:3.42 Å, 3.66 Å
  • Epitope_Length:28.0
  • Epitope_position: 403 ; 405 ; 408 ; 415 ; 416 ; 417 ; 421 ; 453 ; 455 ; 456 ; 457 ; 458 ; 459 ; 460 ; 473 ; 474 ; 475 ; 476 ; 477 ; 486 ; 487 ; 489 ; 498 ; 500 ; 501 ; 502 ; 504 ; 505
Antigenic clustering results between representative variants
  • AAA(SARS)
  • AAB(BatCoV)
  • AAC(SARS-CoV-2)
Heatmap based on antigenicity results between representative variants