spike_validated_epi_5

• Epitope_Source： Sars-Cov-2 epitope in PDB database
• Antibody：Antibody CR3022
• Literature：
  Yuan M, Wu NC, Zhu X, et al. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science. 2020;368(6491):630‐633. doi:10.1126/science.abb7269 Yuan M, Liu H, Wu NC, Lee CD, Zhu X, Zhao F, Huang D, Yu W, Hua Y, Tien H, Rogers TF, Landais E, Sok D, Jardine JG, Burton DR, Wilson IA. Structural basis of a shared antibody response to SARS-CoV-2. Science. 2020 Aug 28;369(6507):1119-1123. doi: 10.1126/science.abd2321. Epub 2020 Jul 13. PMID: 32661058; PMCID: PMC7402627. Huo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI. Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike. Cell Host Microbe. 2020 Sep 9;28(3):445-454.e6. doi: 10.1016/j.chom.2020.06.010. Epub 2020 Jun 19. Erratum in: Cell Host Microbe. 2020 Sep 9;28(3):497. PMID: 32585135; PMCID: PMC7303615. Huo J, Le Bas A, Ruza RR, Duyvesteyn HME, Mikolajek H, Malinauskas T, Tan TK, Rijal P, Dumoux M, Ward PN, Ren J, Zhou D, Harrison PJ, Weckener M, Clare DK, Vogirala VK, Radecke J, Moynié L, Zhao Y, Gilbert-Jaramillo J, Knight ML, Tree JA, Buttigieg KR, Coombes N, Elmore MJ, Carroll MW, Carrique L, Shah PNM, James W, Townsend AR, Stuart DI, Owens RJ, Naismith JH. Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. Nat Struct Mol Biol. 2020 Sep;27(9):846-854. doi: 10.1038/s41594-020-0469-6. Epub 2020 Jul 13. PMID: 32661423.
• PDBID：6W41, 6YLA, 6YM0, 6XC7, 6XC3, 6YOR, 6ZH9-E, 7A5R, 7A5S
• PDB_Method：X-RAY, EM
• PDB_Resolution：3.08 Å, 2.42 Å, 4.36 Å, 2.88 Å, 2.70 Å, 3.30 Å, 3.31 Å, 3.70 Å, 3.90 Å
• Epitope_Length：26.0
• Epitope_position： 369 ; 370 ; 371 ; 372 ; 374 ; 376 ; 377 ; 378 ; 379 ; 380 ; 381 ; 382 ; 383 ; 384 ; 385 ; 386 ; 390 ; 392 ; 428 ; 429 ; 430 ; 515 ; 516 ; 517 ; 518 ; 519