Disorder "Type 1 Diabetes Mellitus"
Found 23 records
Disorder information
Disorder name:
Type 1 Diabetes Mellitus
Disoder ID:
OMIM entry:
Synonyms:
type I diabetes mellitus, insulin-dependent diabetes mellitus, IDDM
Definition:
A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin.
Modifier statisitcs
Record:
23
Gene:
6
Variant:
11
Reference:
13
Effect type:
Expressivity(23)
Modifier effect:
Risk factor(20)
,Altered susceptibility(2)
,Altered immune response(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| IFIH1 | IFIH1:c.2807+1G>A | Expressivity | Risk factor | OR=0.74, 95% CI: (0.59-0.94), P=1.2×10(-2) | Reduced risk of T1DMmore | more |
| IFIH1:c.1641+1G>C | Expressivity | Risk factor | OR=0.68, 95% CI: (0.56-0.83), P=1.1×10(-4) | Reduced risk of T1DMmore | more | |
| HLA | HLA:DRB1*0405-DQB1*0401 | Expressivity | Risk factor | Higher in groups a and b than in group c (P=0.021 and 0.0395, respectively) | The -1123G>C SNP in the PTPN22 gene promoter and HLA DRB1*0405-DQB1*0401 might influence the concurrence of systemic and organ-specific ADs in patients with type 1 diabetesmore | more |