Variant "HLA:DRB1*0405-DQB1*0401"
Search result: 1 record
Variant information
Gene:
HLA 
Variant:
HLA:DRB1*0405-DQB1*0401 
dbSNP ID:
no data 
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor(1)  
Detail：
  • Target disease:
    Type 1 Diabetes Mellitus (DOID_9744)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    Higher in groups a and b than in group c (P=0.021 and 0.0395, respectively) 
    Effect:
    The -1123G>C SNP in the PTPN22 gene promoter and HLA DRB1*0405-DQB1*0401 might influence the concurrence of systemic and organ-specific ADs in patients with type 1 diabetes
    Reference:
    PMID29762907
    Title:
    Genetic differences between type 1 diabetes with and without other autoimmune diseases.
    Species studied:
    Human
    Abstract:
    Clusters of autoimmune diseases (ADs) are present in some people with type 1 diabetes. This clustering suggests the existence of common genetic backgrounds for abnormal autoimmunity in these individuals. However, the genetic differences between type 1 diabetes patients with and without other ADs are not well known.