Disorder "Head And Neck Carcinoma"
Found 2 records
Disorder information
Disorder name:
Head And Neck Carcinoma
Disoder ID:
Synonyms:
carcinoma of the neck
Definition:
A tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx.
Modifier statisitcs
Record:
2
Gene:
2
Variant:
2
Reference:
1
Effect type:
Expressivity(2)
Modifier effect:
Association between smoking and HNC(2)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| ERCC6 | ERCC6:c.1821+7C>T | Expressivity | Association between smoking and HNC | CC+CT vs. TT; OR=0.62; 95% CI: 0.45-0.86 | rs4253132 on ERCC6 was associated with decreased HNC oddsmore | more |
| ERCC3 | ERCC3:c.471+118G>A | Expressivity | Association between smoking and HNC | AA+AG vs. GG; OR=1.28; 95% CI: 1.01-1.61 | rs4150403 on ERCC3 was associated with increased HNC oddsmore | more |
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