Gene "ERCC3"
Found 1 record
Gene information
Gene symbol:
ERCC3
See related:
Ensembl: ENSG00000163161, Gene ID: 2071
Additive variants :
Detected
Genetic interaction partners
No data
Modifier statisitcs
Record:
1 
Disorder:
1 
Vriant:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Association between smoking and HNC(1)  
Detail：
  • Variant 1:
    ERCC3:c.471+118G>A
    Gene:
    ERCC3
    Genomic location:
    chr2:128050068
    dbSNP ID:
    rs4150403
    Target disease:
    Head And Neck Carcinoma(DOID_1542)
    Effect type:
    Expressivity 
    Modifier effect:
    Association between smoking and HNC 
    Evidence:
    AA+AG vs. GG; OR=1.28; 95% CI: 1.01-1.61 
    Effect:
    rs4150403 on ERCC3 was associated with increased HNC odds
    Reference:
    PMID23720401
    Title:
    Single-nucleotide polymorphisms in nucleotide excision repair genes, cigarette smoking, and the risk of head and neck cancer.
    Species studied:
    Human
    Abstract:
    Cigarette smoking is associated with increased head and neck cancer (HNC) risk. Tobacco-related carcinogens are known to cause bulky DNA adducts. Nucleotide excision repair (NER) genes encode enzymes that remove adducts and may be independently associated with HNC, as well as modifiers of the association between smoking and HNC.