Disorder "Mental Deterioration"
Found 6 records
Disorder information
Disorder name:
Mental Deterioration
Disoder ID:
Definition:
Loss of previously present mental abilities, generally in adults.
Modifier statisitcs
Record:
6
Gene:
2
Variant:
4
Reference:
3
Effect type:
Expressivity(6)
Modifier effect:
Altered IL-1 beta production levels(2)
,Altered klotho levels(2)
,Risk factor and altered life span(2)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| KL | KL:c.1054T>G(p.Phe352Val) | Expressivity | Risk factor and altered life span | 1.57-fold (95% CI: 1.23 to 1.98) increased odds ratio (or) for 5-year survival in two independent populations (p<0.0002) | The KL-VS allele confers a heterozygous advantage in conjunction with a marked homozygous disadvantage for HDL-C levels, SBP, stroke, and longevitymore | more |
| KL:c.1054T>G(p.Phe352Val) | Expressivity | Altered klotho levels | Study on animal models | This allele increased klotho levels in serum enhance cognition and counteract cognitive deficits at different life stages.more | more | |
| KL:c.1109G>C(p.Cys370Ser) | Expressivity | Risk factor and altered life span | 1.57-fold (95% CI: 1.23 to 1.98) increased odds ratio (or) for 5-year survival in two independent populations (p<0.0002) | The KL-VS allele confers a heterozygous advantage in conjunction with a marked homozygous disadvantage for HDL-C levels, SBP, stroke, and longevitymore | more | |
| KL:c.1109G>C(p.Cys370Ser) | Expressivity | Altered klotho levels | Study on animal models | This allele increased klotho levels in serum enhance cognition and counteract cognitive deficits at different life stages.more | more | |
| CASP1 | CASP1:c.10643C | Expressivity | Altered IL-1 beta production levels | P<0.02 | Subjects carrying the variants 10643C and 5352A allele had significantly lower IL-1 beta production levels, The haplotype with two variants present (10643C and 5352A) was associated with better executive function compared to the reference haplotype without variants.more | more |
| CASP1:c.5352A | Expressivity | Altered IL-1 beta production levels | P<0.02 | Subjects carrying the variants 10643C and 5352A allele had significantly lower IL-1 beta production levels, The haplotype with two variants present (10643C and 5352A) was associated with better executive function compared to the reference haplotype without variants.more | more |
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