Disorder "Migraine"
Found 3 records
Disorder information
Disorder name:
Migraine
Disoder ID:
OMIM entry:
Synonyms:
migraine disorder,migraine variant,migraine with or without aura
Definition:
Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.
Modifier statisitcs
Record:
3
Gene:
3
Variant:
3
Reference:
3
Effect type:
Expressivity(3)
Modifier effect:
Altered susceptibility(1)
,Altered sensorimotor symptoms(1)
,Risk factor(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| SOD2 | SOD2:c.47T>C(p.Ala16Val) | Expressivity | Risk factor | P=0.042 | Our findings suggest that SOD2 is a disease-modifier gene influencing oxidative mechanisms in MwA.more | more |
| CACNA1A | CACNA1A:c.1360G>A(p.Ala454Thr) | Expressivity | Altered sensorimotor symptoms | Pedigree analysis | That genetic variation in CACNA1A may be not only a cause but also a modifier of migraine phenotype.more | more |
| BDNF | BDNF:c.283G>A(p.Val95Met) | Expressivity | Altered susceptibility | OR=1.22, 95% CI: 1.05-1.41, P=0.011 | BDNF rs6265 may act as a genetic susceptibility factor for migrainemore | more |
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