Disorder "Myocardial Infarction"
Found 2 records
Disorder information
Disorder name:
Myocardial Infarction
Disoder ID:
OMIM entry:
Synonyms:
Myocardial infarct,heart attack
Definition:
Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin.
Modifier statisitcs
Record:
2
Gene:
2
Variant:
2
Reference:
2
Effect type:
Expressivity(2)
Modifier effect:
Risk factor(2)
Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
---|---|---|---|---|---|---|
KCNH2 | KCNH2:c.2690A>C(p.Lys897Thr) | Expressivity | Risk factor | Patients with an acute MI carrying the KCNH2-K897T polymorphism had an 8-fold greater risk of experiencing TdP compared with controls (95% confidence interval = 2-40) | The common K897T polymorphism is associated with an increased risk of TdP developing in the subacute phase of MImore | more |
GCLM | GCLM:c.588C>T | Expressivity | Risk factor | CT and T genotypes: 31.5% in MI group versus 19.2% in control group; p<0.001 | The 588T polymorphism of the GCLM gene may suppress GCLM gene induction in response to oxidants and that it is a genetic risk factor for MImore | more |
Total 2,Each Page
,Jump To
Page