Disorder "Rheumatoid Arthritis"
Found 6 records
Disorder information
Disorder name:
Rheumatoid Arthritis 
Disoder ID:
OMIM entry:
Synonyms:
Arthritis or polyarthritis, rheumatic,atrophic Arthritis 
Definition:
Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures. 
Modifier statisitcs
Record:
Gene:
Variant:
Reference:
Effect type:
Expressivity(6)  
Modifier effect:
Risk factor(6)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
TYK2 TYK2:c.2051T>G(p.Ile684Ser) Expressivity  Risk factor  OR=0.86, P=4.6×10(-7)  Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore more
TYK2:c.2783C>T(p.Ala928Val) Expressivity  Risk factor  OR=0.53, P=1.2×10(-9)  Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore more
TYK2:c.3310C>G(p.Pro1104Ala) Expressivity  Risk factor  OR=0.66, P=2.3×10(-21)  Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore more
IL6R IL6R:c.*4066A>G Expressivity  Risk factor  P=0.02, P corrected = 0.05  IL6R SNP was more significantly associated with joint damage between the two IL-6R SNPs with the degree of joint destruction in RA.more more
IL6R:c.86-1657G>T Expressivity  Risk factor  P=0.0058, P corrected = 0.026  IL6R SNP was more significantly associated with joint damage between the two IL-6R SNPs with the degree of joint destruction in RA.more more
IL6 IL6:c.-174C>G Expressivity  Risk factor  OR=3.750, 95% CI:1.800-7.813, P<0.001  IL-6-174G>C SNP is significantly associated with increased RA risk in overall, and specifically in Asian populationmore more
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