Disorder "Rheumatoid Arthritis"
Found 6 records
Disorder information
Disorder name:
Rheumatoid Arthritis
Disoder ID:
OMIM entry:
Synonyms:
Arthritis or polyarthritis, rheumatic,atrophic Arthritis
Definition:
Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures.
Modifier statisitcs
Record:
6
Gene:
3
Variant:
6
Reference:
3
Effect type:
Expressivity(6)
Modifier effect:
Risk factor(6)
Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
---|---|---|---|---|---|---|
TYK2 | TYK2:c.2051T>G(p.Ile684Ser) | Expressivity | Risk factor | OR=0.86, P=4.6×10(-7) | Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore | more |
TYK2:c.2783C>T(p.Ala928Val) | Expressivity | Risk factor | OR=0.53, P=1.2×10(-9) | Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore | more | |
TYK2:c.3310C>G(p.Pro1104Ala) | Expressivity | Risk factor | OR=0.66, P=2.3×10(-21) | Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore | more | |
IL6R | IL6R:c.*4066A>G | Expressivity | Risk factor | P=0.02, P corrected = 0.05 | IL6R SNP was more significantly associated with joint damage between the two IL-6R SNPs with the degree of joint destruction in RA.more | more |
IL6R:c.86-1657G>T | Expressivity | Risk factor | P=0.0058, P corrected = 0.026 | IL6R SNP was more significantly associated with joint damage between the two IL-6R SNPs with the degree of joint destruction in RA.more | more | |
IL6 | IL6:c.-174C>G | Expressivity | Risk factor | OR=3.750, 95% CI:1.800-7.813, P<0.001 | IL-6-174G>C SNP is significantly associated with increased RA risk in overall, and specifically in Asian populationmore | more |
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