Disorder "Type 1 Diabetes Mellitus"
Found 23 records
Disorder information
Disorder name:
Type 1 Diabetes Mellitus 
Disoder ID:
OMIM entry:
Synonyms:
type I diabetes mellitus, insulin-dependent diabetes mellitus, IDDM 
Definition:
A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin. 
Modifier statisitcs
Record:
23 
Gene:
Variant:
11 
Reference:
13 
Effect type:
Expressivity(23)  
Modifier effect:
Risk factor(20) ,Altered susceptibility(2) ,Altered immune response(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
TYK2 TYK2:c.2783C>T(p.Ala928Val) Expressivity  Risk factor  OR=0.53, P=1.2×10(-9)  Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore more
TYK2:c.2051T>G(p.Ile684Ser) Expressivity  Risk factor  OR=0.86, P=4.6×10(-7)  Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore more
TYK2:c.3310C>G(p.Pro1104Ala) Expressivity  Risk factor  OR=0.66, P=2.3×10(-21)  Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore more
SUMO4 SUMO4:c.163G>A(p.Val55Met) Expressivity  Altered immune response  A:G = 146:135 versus 136:124; χ2 = 0.007; P=0.935  The 163A→G SNP (rs237025; resulting in the amino acid substitution M55V) influences immune responses by modulating NFκB activity.more more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Risk factor  A:G = 146:135 versus 136:124; χ2 = 0.007; P=0.935  The 163G allele was associated with increased risk for T1D in a collection of European American families.more more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Risk factor  Assessment of genotype–phenotype associations  SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.more more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Risk factor  In asian population (A versus G: OR=0.79, 95% CI:0.72-0.86, P=0.000) and in caucasian population (A versus G: OR=0.84, 95% CI:0.73-0.97, P=0.007)  We detected a significant association of SUMO4 M55V polymorphism with T1DM in Asian population (A versus G: OR=0.79, 95%CI=0.72-0.86, p=0.000) and a significant association of SUMO4 M55V polymorphism with T1DM in Caucasian population (A versus G: OR=0.84, 95%CI=0.73-0.97, p=0.007).more more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Altered susceptibility  OR=1.236, 95% CI: 1.112-1.373, P=7.9×10(-6)  The SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.more more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Risk factor  OR=1.30, 95% CI: (0.54–3.12), P=0.55  The M55V polymorphism has been shown to be associated with susceptibility to T1DM in Asiansmore more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Altered susceptibility  P<0.05, OR=1.51, 95% CI: 1.03-2.13  The SUMO4 gene M55V variant is associated with the genetic susceptibility of T1D in Chinese children.more more
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