Disorder "Atrial Fibrillation"
Found 2 records
Disorder information
Disorder name:
Atrial Fibrillation 
Disoder ID:
Synonyms:
A-fib 
Definition:
An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute. 
Modifier statisitcs
Record:
Gene:
Variant:
Reference:
Effect type:
Expressivity(2)  
Modifier effect:
Altered onset time(1) ,Altered severity(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
KCNH2 KCNH2:n.150623137C>T Expressivity  Altered onset time  OR=2.40, P=0.001  The variant rs2968863 (7q36.1), reported in GWAS to shorten the QTc interval, was found to be associated with early-onset lone AFmore more
ABCB4 ABCB4:c.523A>G(p.Thr175Ala) Expressivity  Altered severity  0.05 vs. 0.01; OR=3.73; 95% CI: 1.16-11.49; P=0.013  rs58238559 in ABCB4 is a rare missense variant with a significant effect on the development of AFL/AF.more more
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