Disorder "Bipolar Disorder"
Found 1 record
Disorder information
Disorder name:
Bipolar Disorder
Disoder ID:
Synonyms:
bipolar depression, Manic Depressive disorder, manic disorder, manic depression, Manic Bipolar Affective disorder, Manic bipolar I disorder, mixed bipolar disorder, bipolar disorder manic phase
Definition:
Bipolar disorder, formerly called manic depression, is a mental health condition that causes extreme mood swings that include emotional highs (mania or hypomania) and lows (depression).
Modifier statisitcs
Record:
1
Gene:
1
Variant:
1
Reference:
1
Effect type:
Pleiotropy(1)
Modifier effect:
Altered amygdala activation(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| COMT | COMT:c.472G>A(p.Val158Met) | Pleiotropy | Altered amygdala activation | P<0.05 | The Met158 allele further reduces cortical efficiency in the vlPFC in individuals with affective morbidity.more | more |
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