Disorder "Cervical Cancer"
Found 13 records
Disorder information
Disorder name:
Cervical Cancer 
Disoder ID:
OMIM entry:
Synonyms:
cervical neoplasm,cervix cancer,cervix uteri cancer,neoplasm of uterine cervix,tumor of the Cervix Uteri,uterine cervical neoplasm 
Definition:
A female reproductive organ cancer that is located_in the cervix. 
Modifier statisitcs
Record:
13 
Gene:
Variant:
Reference:
Effect type:
Expressivity(13)  
Modifier effect:
Risk factor(13)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
TLR9 TLR9:rs187084 Expressivity  Risk factor  Age-adjusted OR=2.165, 95% CI: 1.267-3.699, P=0.005  TLR4rs11536889 CC (age-adjusted OR, 2.469 [95% CI, 1.499 to 4.065]; p < 0.001) andTLR9rs187084 TC (age-adjusted OR, 2.165 [95% CI, 1.267-3.699]; P=0.005) genotypes showed the higher distribution in cervicitis patients compared to controls. Inmore more
TLR9:rs187084 Expressivity  Risk factor  P=0.001, age-adjusted OR=2.915,95% CI: 1.508–5.635  Individuals carrying heterozygous genotype of rs4986790 [p=0.033, age-adjusted OR=1.693 (1.043–2.747)], rs1927911 [p=0.032, age-adjusted OR=1.896 (1.055–3.406)] and rs187084 [p=0.001, age-adjusted OR=2.915 (1.508–5.635)] showed significant association with the presence of HPV 16 and 18 infections.more more
TLR9:rs187084 Expressivity  Risk factor  P=0.01  A significant difference in the distribution of genotype frequencies between the cases and the controls were observed for TLR4 SNPs rs11536889 (p=0.013) and rs1927911 (p=0.04) as well as TLR9 SNPs rs187084 (p=0.01) and rs352139 (p=0.04).more more
TLR9:rs352139 Expressivity  Risk factor  P=0.04  A significant difference in the distribution of genotype frequencies between the cases and the controls were observed for TLR4 SNPs rs11536889 (p=0.013) and rs1927911 (p=0.04) as well as TLR9 SNPs rs187084 (p=0.01) and rs352139 (p=0.04).more more
TLR4 TLR4:rs1153688 Expressivity  Risk factor  Age-adjusted OR=1.632, 95% CI: 1.132 to 2.352; P=0.009  TLR4 rs11536889 C allele was shown to increase the risk of cervicitis (age-adjusted OR, 1.632 [95% CI, 1.132 to 2.352]; P=0.009) compared to controls.more more
TLR4:rs11536889 Expressivity  Risk factor  Age-adjusted OR=2.469, 95% CI: 1.499 to 4.065; P<0.001  TLR4rs11536889 CC (age-adjusted OR, 2.469 [95% CI, 1.499 to 4.065]; p < 0.001) andTLR9rs187084 TC (age-adjusted OR, 2.165 [95% CI, 1.267-3.699]; P=0.005) genotypes showed the higher distribution in cervicitis patients compared to controls. Inmore more
TLR4:rs11536889 Expressivity  Risk factor  P=0.013  A significant difference in the distribution of genotype frequencies between the cases and the controls were observed for TLR4 SNPs rs11536889 (p=0.013) and rs1927911 (p=0.04) as well as TLR9 SNPs rs187084 (p=0.01) and rs352139 (p=0.04).more more
TLR4:rs1927911 Expressivity  Risk factor  P=0.032, age-adjusted OR=1.896, 95% CI: 1.055–3.406  Individuals carrying heterozygous genotype of rs4986790 [p=0.033, age-adjusted OR=1.693 (1.043–2.747)], rs1927911 [p=0.032, age-adjusted OR=1.896 (1.055–3.406)] and rs187084 [p=0.001, age-adjusted OR=2.915 (1.508–5.635)] showed significant association with the presence of HPV 16 and 18 infections.more more
TLR4:rs1927911 Expressivity  Risk factor  P=0.04  Individuals carrying heterozygous genotype of rs4986790 [p=0.033, age-adjusted OR=1.693 (1.043–2.747)], rs1927911 [p=0.032, age-adjusted OR=1.896 (1.055–3.406)] and rs187084 [p=0.001, age-adjusted OR=2.915 (1.508–5.635)] showed significant association with the presence of HPV 16 and 18 infections.more more
TLR4:D299G Expressivity  Risk factor  P=0.033, age-adjusted OR=1.693, 95% CI: 1.043–2.747  Individuals carrying heterozygous genotype of rs4986790 [p=0.033, age-adjusted OR=1.693 (1.043–2.747)], rs1927911 [p=0.032, age-adjusted OR=1.896 (1.055–3.406)] and rs187084 [p=0.001, age-adjusted OR=2.915 (1.508–5.635)] showed significant association with the presence of HPV 16 and 18 infections.more more
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